Beside Ninja Noise (nj), clone is one of the Photoshop (CS3/CS4) function that I use most...
All of my picture use nj to remove the noise because even @iso100 picture consist noise while zoom to 100% ....
another big challenge for macro shooter is sensor dust, so normally we use clone to remove the sensor dust .. ..
And I apply this clone technique to clone away the reflective portion of the object
1. open the file with other necessary PP (curve, crop ..... )
2. duplicate a layer
3. change the opacity of the layer to ~40-60% depend the natural look
4. then use the "clone" tool
5. clone those reflective area with adjacent area color.... and this is the sample outcome
clone picture (final output)